Several ppl have reported it showing up again on trendmicro scans after opening mIRC. Regarding that, all we know is what is already said several times in this thread.
If your question was about why you "try to open mirc i fail", we need a bit more info. Do you mean you cant bring mIRC up when you click on the shortcut, or cant connect to a server or what? If you can tell us exactly what happens and any error msgs, we might be able to help.