Loaded a copy just with:

"
[user]
MY INFO

[about]
version=
show=no
portable=yes
"

Click Address Book > Nick Colors > [Enable nick colors] > Add:

1) $me = Orange (Messages and Listbox)
2) [Auto-color based on nick] (Messages and Listbox) (Just for testing, I usually do just Messages on this one)

Code
[cnicks]
n0=$me,7,,,0,0,0,0,0,0
n1=,99,,,1,1,0,0,0,1


/server irc.rizon.net (not even SSL, not relevant for this test)

/join a big chan

Press Alt+K > see the nicklist colors all change immediately.

NOTE that they only change ONCE for every mIRC start so you will have to press ALT+K AFTER you join the chan, if you press it before joining the new set or colors will already be defined and mIRC will need to be restarted.

Last edited by eahm; 29/03/22 05:53 PM. Reason: Changed Click with Press. Changed All for better understanding the line.