1)Are you using a "clean" mIRC or a script?
Scripts might have a protection mechanism that will unload every script on load. In that case, try typing:
/load -nrs script.ini
to deter the script from unloading your remote.
2)Make sure mIRC is listening to all CTCPs, Events and Raws. (Tools->Remote->Listen->enable all)
3)When a script is loaded, an echo informs you that it was successful. e.g.:
* Loaded remotes 'C:\mIRC\script.ini'
Check these out