Yeah I agree with sparta, although I only remember this occuring in Windows XP...I don't remember it happening in Windows 98 when I used it, but that was on a computer that would hardly stay up for more than 30 seconds...so who knows!
Anyway, I often find that program icons will just randomly disappear from systray. I first thought this might be some sort of virus, but I am virus-free. Due to this thread, I will now check if there is a link between CPU usage and icons in the systray.
Personally, I do not have the option to put the mIRC icon in the systray checked - for now, you might like to disable this option. If you're concerned of others using the program you can set a password on it (ALT+O > General > Lock) and then use CTRL+Minimise - then when you try to maximise it, the password will be requested.
Happy chatting!
Regards,