I guess the icon idea (triangle or green arrow) pointing at the 'Select' button isn't quite doing it for people.
New suggestion: Frame the select button inside a red rectangle or 3d border's edge, and replace the icon with a worded statement. "Click 'Select' to use changes."
People are still thinking that mIRC is broken because they believe it won't accept their server edits when they attempt to Edit-Then-Reconnect.