I must apologize profusely. I am completely at fault here. Obviously, longevity has nothing whatsoever to do with ability to read a thread in its entirety. I did not go back and reread the entire thread. I read Collective's post(s) as meaning that "to make any script active, you have to restart mIRC." I am completely and utterly in error. Of course you have to restart mIRC for an on START event to fire. Doh! Please accept my apologies for being an idiot. (Here, you can take back my Oscar now as well.)

There is a way to test out your on START event without restarting mIRC, though (although not as I had originally shown it above).
Code:
;  
on *:START: StartUp.Connect
;
alias StartUp.Connect {
  server kernel-c.nj.us.dal.net 7000 -i Nick1 Nick2 -j #mIRC,#HelpDesk
  server -m irc.Qeast.net 6667 -i Nick3 Nick4 -j #mIRC
  server -m barrysworld3.uk.quakenet.org 6667 -i Nick5 Nick6 -j #mIRC,#Help
}

Place the code it will execute inside an alias (which you can eventually make a local alias with alias -l after you are satisfied with it) and call the alias from your on START event. You can then execute the on START stuff again at any time by closing all your connections and calling the alias yourself with /StartUp.Connect from the command line.