Personally, It dosn't bother me at all... But I have a key.
I think that as mIRC is primarily text a text add (such as seen in Windows Live Messenger conversation windows) is more suitable as mIRC is mostly text based.
Perhaps adding a status bar with a customizable text/click area (on left) and advertisement on right?
I think it would be a better alternative and would allow several ads per session...
Please dont try and put in a "relevant ads" page.... The fact google does that freaks me out when I use gmail.