I was testing out some stuff on my friends mac the other day and decided to try mirc using crossover (a program for mac os which allows you to run windows apps inside mac os). I found that it works very well! however, quite a few operating-system-side functions do not work. i doubt coms and dlls will work. To get audio to work, simply install windows media player onto crossover and it will work fine, except for volume control which will not work. i have not tested many features, but IRC works fine and everything is running very well!
This info may be useful to people using Macs.