I have never used this, but could u maybe bring mirc forward so it is the active app when it needs you to answer?
I've tried that already and it's not a solution, due to 2 things:
- When I'm gaming it can screw everything up, either make colors/gamma go weird or totally crash the game.
- When mirc popups I could just read what was said and type a response, voice would be obsolete then.