You double checked to be sure you have autoget checked in file/options/dcc? did you click the "trusted" button and be sure you dont have it set to trusted users only?
-you could have a script blocking users. mite check in the addy book (click on the icon or hold down your alt key and click the b key) under ignore to see if any names are there
-file/options/general/lock. anything checked there?
-the network could require you to dccallow the sender for certain file types
-file/options/dcc/folders, look in the dcc ignore area
-the sender could be using fserv and sent you a msg to enable yours
-the sender could be the one with the problem
-are you sure the file in question wasnt already on your machine? (mIRC would then ask what you want to do with it if you have it set to do that)