Here is what did work...

The solution:
Have the app tell Windows that it is not DPI aware and let it scale everything properly. (Granted, this is not the ideal solution, but it does make the app usable again)

  • Press Windows Button + R, type regedit, and then click OK.
  • Navigate to the following registry subkey:
    HKEY_LOCAL_MACHINE > SOFTWARE > Microsoft > Windows > CurrentVersion > SideBySide
  • Right-click, select NEW > DWORD (32 bit) Value
  • Type PreferExternalManifest, and then press ENTER.
  • Right-click PreferExternalManifest, and then click Modify.
  • Enter Value Data 1 and select Decimal.
  • Click OK. Exit Registry Editor.



mirc.exe.manifest
Code:
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

<assembly xmlns="urn:schemas-microsoft-com:asm.v1" manifestVersion="1.0" xmlns:asmv3="urn:schemas-microsoft-com:asm.v3">

<dependency>
  <dependentAssembly>
    <assemblyIdentity
      type="win32"
      name="Microsoft.Windows.Common-Controls"
      version="6.0.0.0" processorArchitecture="*"
      publicKeyToken="6595b64144ccf1df"
      language="*">
    </assemblyIdentity>
  </dependentAssembly>
</dependency>

<dependency>
  <dependentAssembly>
    <assemblyIdentity
      type="win32"
      name="Microsoft.VC90.CRT"
      version="9.0.21022.8"
      processorArchitecture="amd64"
      publicKeyToken="1fc8b3b9a1e18e3b">
    </assemblyIdentity>
  </dependentAssembly>
</dependency>

<trustInfo xmlns="urn:schemas-microsoft-com:asm.v3">
  <security>
    <requestedPrivileges>
      <requestedExecutionLevel
        level="asInvoker"
        uiAccess="false"/>
    </requestedPrivileges>
  </security>
</trustInfo>

<asmv3:application>
  <asmv3:windowsSettings xmlns="http://schemas.microsoft.com/SMI/2005/WindowsSettings">
    <ms_windowsSettings:dpiAware xmlns:ms_windowsSettings="http://schemas.microsoft.com/SMI/2005/WindowsSettings">false</ms_windowsSettings:dpiAware>
  </asmv3:windowsSettings>
</asmv3:application>

</assembly>