Forums Bug Reports mIRC does not remember loaded files

I would say try loading your scripts, shut down mIRC,
then open mIRC again, could be worth a shot imo. It
seems to me that variables behave the same way, any
variables that are set are not saved to file until mIRC
exits clean, and yes it's annoying as hell on the rare
occasion that it happens to me, which is pretty much
only due to power failures.

~ Edit ~
Then again there is the /saveini command.