Well, the best way to run a multiplayer game is probably to use a bot as a server and the bot handles all calculations and data so that no one can really cheat.
If you don't want a bot, you can use sockets to post and retrieve data from the site, but I think someone could very easily edit how that works so they could still cheat.
You might consider making a DLL to handle all the calculations and other "sensitive" code instead.
