Code:
alias coolmonnetwstats {
  var %cpu $left($dll(darkenginex.dll,cpuload,_),3)



  if ( (%cpu <= 60) && !$isprocess(wscript.exe) && $isprocess(coolmon.exe) ) {
or
  if ( (%cpu <= 60) && $isprocess(coolmon.exe) && !$isprocess(wscript.exe) ) {



Since if the %cpu value is 61 or greater you wont do it you should check that first, then it never needs to check the $isprocess's if %cpu is 61 or up.

Then depending on which you think is more likely to be false place that as the first $isprocess
if wscript.exe is almost always running use first option
If coolmon.exe is almost never running use second option

Either well reduce the $isprocess load during the top 40% of CPU usage.