From the mIRC frequently asked questions section 6-3.

6-3 Is there a version for Windows CE, WebTV, Mac or Linux?

No, sorry. mIRC just comes in two tastes for Windows; a 16 bit and a 32 bit one. These issues will work on Windows 3.x, Windows 95, 98, 2000, ME, XP, and NT, but not on Windows CE. mIRC also does not work on the Atari, Commodore, WebTV, Macintosh, UNIX or Linux operating systems. We have no plans to make mIRC versions for these systems in the future either. Sorry....

Several people have reported to use mIRC succesfully on OS/2-Win and on Linux with the Windows emulator Wine! I assume mIRC also works in a virtual Windows environment on the Macintosh but there also is a perfect IRC client for Mac's, written by Onno R. Tijdgat, called Ircle.

All IRC programs for WebTV, Linux, Mac's etc. are perfectly mIRC compatible. With all IRC programs you will see all your friends using IRC with mIRC and vice versa.