Sounds to me like their systems need some general maintenance. I have colours allocated to all mode prefixes (@,+,-), normal users, 10min idlers, 30min idlers and those on ignore list. I have also a plethora of scripts running and mIRC is stable regardless of the room size.

These others should check available disc space, the last time the disc was cleaned up/defragmented and also check for memory leaks in any programmes and available memory by monitoring the task manager while online.