A few ppl have reported puters crashing during dcc/xdcc. Some report a DRIVER_IRQL_NOT_LESS_OR_EQUAL error.

Are you running any of the so called "speed patches" supposed to boost d/l? (they can also make some registry changes) Linksys and netgear routers or some NIC (seems to me nividia was one of them) have occasionally been found to be the cause. Is possible it could be the MTU values in 2k but i'd leave that to last to consider. Make sure you have the latest firmware/drivers. Try not using port 6667 to connect to a network server. Run a search here, set to All FOrums, expand to all dates and try search terms like BSOD or xdcc or dcc or crash to read the other threads on this.