I got it working!!

Final Code

Code:
on *:text:*:#exuviax: {
  var %one { $read(C:\Users\Randy\Documents\Streamtip\tip-recent.txt,n,1) }
  var %two { $read(C:\Users\Randy\AppData\Roaming\mIRC\check.txt,n,1) }
  if (%two isin %one) { return }
  msg # New Donation: %one 
  write -c check.txt %one
}

I do things with stuff that makes other things do stuff.