A crash is when mirc.exe is shutdown by Windows because he did an invalid operation, you cannot get back to mIRC in any way, a freeze is when you try to do a lot of stuff and it requires time to do them, but in this case mIRC will get back to a working state.
Are you experiencing a crash or a freeze?
How many lines in BOTH files at the time of the crash/freeze?
How many nickname in the channel at the time of the crash/freeze?