if you have mirc be in a folder beneath c:\program files\ you'll need to leave your .ini's where the installer put them, in C:\Users\USERNAME\AppData\Roaming\mIRC

mirc will run perfectly fine if you move the whole contents of your current mirc folder beneath program files over to somewhere else like c:\mirc\ or c:\MyApps\mirc\ if you want to keep mirc.ini and mirc.exe in the same folder, as long as your mirc.ini and other ini's mention paths only as being relative to the mirc folder itself. i.e. referring to your sound folder as =sounds\ and not c:\path\path\mirc\sounds\