Personally, I'd like to see the 6-bit RGB palette added to mIRC.
Control-k plus two numerical digits. 00 through 15 would definitely stay the same. I'd suggest making 20 through 83 be made into the 64 colour palette, but not in sequential order.

The reds and red-likes would closely match those four reds within that range it's replacing. 20, 36, 52, and 68 would be replaced by the four most red colours in the 64 palette colour. And so on with the other colours, as best as possible. This way it won't be too odd for those who are using old clients.