There may be more efficient ways of doing this, but here's an option.
Code:
on *:text:*:#:{
  var %a = 1, %b = $0
  while %a <= %b {
    if $remove($gettok($1-,%a,32),$chr(44)) isnum 100000- {
      .msg $chan The number $gettok($1-,%a,32) was said.
    }
    inc %a
  }
}

Note: This will activate for every number that is said if the number is 100000 or higher.
If one person said 100010 100,020
Then the script will activate twice. Once for the 100010 and once for the 100,020.