I'm in as administrator with full permission. + There is a way to open every program with admin rights. But it don't help. After this i desactivate the full user management. Same result.

I installed about 50 programs in Vista and all working very fine > Games, Appz, Freeware, VIRC, etc. the same way, but mIRC.exe is the only one with these troubles.

Thanks anyway, for this try