I find solution in mozillazine forum
cite:
Handle With Care
Joined: 15 Sep 2004
PostPosted: Jan Sun 15th 2006 1:35pm
Not sure what you mean in your question, but assuming you want to be able to double click a URL in mIRC and have it open in Firefox, here's your answer:

The current version (6.16) of mIRC and previous versions have a bug in it where clicking on a URL often opens MSIE instead of another browser. This may be corrected in a new version of mIRC, which is rumored to be being worked on. In any event, until Khaled gets mIRC fixed, you will need to add the following in your mIRC remotes:

on ^*:HOTLINK:http*//*.*:*:return
on *:HOTLINK:http*//*.*:*:run "C:\Program Files\Mozilla Firefox\mozilla.exe" $1-
on ^*:HOTLINK:www.*:*:return
on *:HOTLINK:www.*:*:run "C:\Program Files\Mozilla Firefox\mozilla.exe" $1-

The above is for default directories for Fx. Flavor to taste according to the path and your browser's executable file.

link forum: http://forums.mozillazine.org/viewtopic.php?p=2020619&highlight=mirc#2020619

Thanks smirk