no,
/me says: /me
* Aenei says: /me

/describe #channel says Action text doesn't have <>
* Aenei says Action text doesn't have <>

/say say Normal text
<Aenei> say Normal text

in either case if you have a "on text" for the word "*say*" it will trigger whether it was action text or normal text.

notices are slightly different depending on if you are the sender or the receiver
/notice mikechat I say this is a notice
-> -mikechat- I say this is a notice
-MikeChat- I say this is a notice