I'm not seeing a problem in 7.49 but I don't think there's a change between the 2 versions. Try putting the following line into a script by itself.

Code:
ctcp *:*:#:{ echo 12 -s CTCP EVENT / (nick) $nick / (chan) # / (CTCP TYPE) $1 (2-) $2- }


Reminder that, just like ON TEXT, this won't reply to actions taken by yourself, so you'll need someone else's help. If there's still no reaction to someone playing a sound or other channel ctcp, see if it works if you move this script to the top script in the list. If it then works, one of your other scripts interfered.