They have an API for all their emotes, so you could use a JSON parser to download them every week or so and set them to a variable in the form of emote1|emote2|emote3 etc.
http://twitchemotes.com/apidocsI'm not really sure how to do that though, and also don't know if it will cause performance issues to have a $regex with 5 billion different words in it :[