There is such a command "reload" with the same parameters as "load" command, to reload a file without triggering the on start/load events in the script being loaded.
I would suggest create such a command to order mirc.exe reload data from mirc.ini file. It would be useful if I change something in mirc.ini file and after that, I could order to reload mirc.ini file to enable those changes.

I would like to see this, although I would think it would be called /loadini to be counterpart to /saveini and reload all mIRC-related INI files. -removed-

~ Edit ~

Nevermind that last part, I realized that the lock options are stored in the Windows registry.

Thirded.

The ideal solution is to make all settings that need to be changed changeable from a proper command, not having to edit the raw mirc.ini file yourself.

That said, this isn't a bad idea, seeing as commands for every single mirc.ini setting would be ridiculously complex