Anything is possible... though we have too little to go by to tell exactly what you're doing or want.
You may find $readini and /writeini especially helpful for Help Macro type scripts.
For Example: (very basic example... add bounds checking to taste.)
on *:TEXT:*!help *:*:{
var %keyword = $2
var %info = $readini(help.ini,help,%keyword)
msg $chan Help for %keyword -- %info
}
the contents of your help.ini file would look like this.
[help]
LOL = Laughing Out Loud!
ROFL = Rolling On the Floor, Laughing!
RTFM = Read The Flippin` Manual!
OMGLOLBBQ = I'm Being Obnoxious Now!
The user would simply type this in the channel:
<SomDumFoo> !help ROFL
- Raccoon