Are you trying to respond to a whisper if someone says hola?
on 1:open:?:*hola*:msg $nick myserver.org
Please consult the help file first. /help on open
Youw ould have found this bit.
on 1:OPEN:?:*hello*:/echo -s $nick just said hello!
This example triggers if the message which trigger on OPEN contained the word hello. This allows you to react to user message in on OPEN instead of waiting for on TEXT to trigger.