I would have, except I got VERY ticked off and just reinstalled a fresh copy of mirc. The fresh copy is working fine, so somewhere along the line of the last two days mirc and Vista weren't happy together.
For future reference, it was only when mirc was active.
So if I minimized mirc, my alt+tab function worked fine, along with the alt=tab+ctrl or the windows+tab uses. But when actively viewing mirc on my Vista computer, those 3 functions failed to change applications.