Although I know a lot people using win vista and mIRC without serious problems (Yes, there is that $getdir thing, probs when not having admin privileges in some circumstances, scarce weird GUI behaviour, that default browser thing etc pp - all that stuff reported here - but mIRC is still usable for chat), I do not question that you might have more serious trouble.
Still, I do question that some kind of nagging will be adjuvant or will cause anything but repulse.
But, instead of telling you to "piss off", I'd rather suggest to have some more patience. Khaled is reading that bug reports, and without doubt, he is working on it. New mIRC releases had never been announced in advance. As the latest version is pre-vista, be sure that fixing things for vista will make up an, if not the important part of the next version.
Personally, I do prefer a working release to a overhasty, premature release.